Last edited by Mikajin
Thursday, July 16, 2020 | History

5 edition of Fluoropyrimidines in cancer therapy found in the catalog.

Fluoropyrimidines in cancer therapy

  • 122 Want to read
  • 36 Currently reading

Published by Humana Press in Totowa, N.J .
Written in English

    Subjects:
  • Fluoropyrimidines -- Therapeutic use.,
  • Cancer -- Chemotherapy.,
  • Colorectal Neoplasms -- drug therapy.,
  • Fluorouracil -- therapeutic use.,
  • Antimetabolites, Antineoplastic -- therapeutic use.,
  • Immunosuppressive Agents -- therapeutic use.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Youcef M. Rustum.
    SeriesCancer drug discovery and development
    ContributionsRustum, Youcef M.
    Classifications
    LC ClassificationsRC271.F55 F58 2003
    The Physical Object
    Paginationxii, 325 p. :
    Number of Pages325
    ID Numbers
    Open LibraryOL21801371M
    ISBN 100896039560
    LC Control Number2002017289

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Fluoropyrimidines in cancer therapy Download PDF EPUB FB2

In Fluoropyrimidines in Cancer Therapy, leading cancer researchers update and review the mechanisms of action and the therapeutic selectivity and efficacy of 5-FU, with and without LV and its prodrugs, in the treatment of colorectal cancer.

Authoritative and integrative, Fluoropyrimidines in Cancer Therapy summarizes the latest preclinical and clinical experiences using fluoropyrimidines to treat colorectal cancer, delineates the underlying mechanisms and choices for therapy, describes the ongoing search to identify ever more effective and selective agents with novel mechanisms of action, and details the development of new mechanism-based combination therapies.

Fluoropyrimidines in cancer therapy. Totowa, N.J.: Humana Press, © (OCoLC) Preclinical and Clinical Modulation G. Peters Dihydropyrimidine Dehydrogenase and Treatment by Fluoropyrimidines: Past and Future Directions Gerard Milano Biochemical Bases of the 5-Fluorouracil-Folinic Acid Interaction and of its Limitations: A.

A Controlled Clinical Trial Including Folinic Acid at Two Distinct Dose Levels in Combination with 5-Fluorouracil (5FU) for the Treatment of Advanced Colorectal Cancer: Experience of the Mayo Clinic and North Central Cancer Treatment Group.

After nearly four decades of clinical experience with the fluoropyrimidines, 5-fluorouracil (5-FU) remains an integral part of chemotherapy for colorectal cancer. A range of 5-FU treatment regimens with or without biochemical modulation are currently used and toxicity appears to be schedule by: Adrienne G.

Waks, Eric P. Winer, in The Breast (Fifth Edition), Fluoropyrimidines. Fluoropyrimidines have been known for decades to be active in breast cancer and have been widely used in both the adjuvant and metastatic settings. Bolus 5-fluorouracil, both alone and in combination with leucovorin (LV), is known to be active in MBC and can be administered on.

Using the escape key closes the listbox and puts you back at the textbox. The radio buttons allow you to toggle between having all search items start with or contain the text you entered in the search box. One of a group of substances used to treat cancer.

A fluoropyrimidine. Fluoropyrimidines are a class of anti-cancer drugs, or more specifically antimetabolites, and include: #N#This article includes a list of related items that share the same name (or similar names). If an internal link incorrectly led you here, you may wish to change the link to point directly to the intended article.

The ASCO Educational Book is peer reviewed by experts in the various fields of oncology and cancer research to ensure the highest scientific integrity and quality. Volume development is directed by an Editorial Board that oversees all aspects of content creation and its review.

Merck & Co., Inc. Boehringer Ingelheim Pharmaceuticals, Inc. Overview. Fluoropyrimidines are antimetabolite drugs widely used in the treatment of solid tumors including colorectal cancer, breast cancer, and cancers of the aerodigestive tract [ 1 – 3 ]. Figure 1 shows candidate genes involved in the pharmacokinetics of three fluoropyrimidine drugs: 5-fluorouracil (5-FU), capecitabine, and by: Get this from a library.

Fluoropyrimidines in cancer therapy: proceedings of the International Symposium on Fluoropyrimidines, Nagoya, Japan, November[Kiyoji Kimura;]. 1. J Clin Oncol. Oct 20;25(30) Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C by: î A radiation oncologist (a doctor who specializes in using radiation to treat cancer) and radiation therapist will define your treatment area.

You may also hear the treatment area referred to as the treatment port or treatment field. These terms refer to the places in your body that will receive radiation. 5-Fluorouracil (5-FU) has been utilized as part of standard chemotherapy for treatment of early-stage and metastatic colorectal cancer for more than 4 decades.

The oral fluoropyrimidines have been studied extensively as an alternative to intravenous by:   Single-Agent Fluoropyrimidines as First-line Therapy for Colorectal Cancer The oral fluoropyrimidines have been compared with 5-FU/LV (Mayo Clinic regimen) in phase 3, randomized trials to evaluate their potential as therapy for colorectal cancer.

Pharmaceutical companies aren't interested in a 'simple cure for cancer' because it hasn't been proved an effective treatment, not because it isn't patentable.

FUDP and FdUDP can also be converted to FUTP and FdUTP and incorporated into RNA and DNA respectively which also contributes to the pharmacodynamic actions of fluoropyrimidines.

Sources: PharmGKB:Fluoropyrimidine Pharmacokinetics, PharmGKB:Fluoropyrimidine Pharmacodynamics, Wikipedia:Fluorouracil. Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients.

The journal primarily covers medical, technical and surgical topics concerning supportive therapy. _____American Cancer Society | cool foods like ice cream or milk shakes because sores in your mouth and throat are making it hard to eat anything.€The type of cancer1, your€treatment,2 and any side effects you have must be considered when trying to figure out the best ways to get the.

Interest in using very high doses of vitamin C as a cancer treatment began as long ago as the s when it was discovered that some properties of the vitamin may make it toxic to cancer cells.

Initial studies in humans had promising results, but these studies were later found to be flawed. Subsequent well-designed, randomized, controlled. The second edition of What to Eat During Cancer Treatment contains more than recipes. The book provides practical tips and suggestions to help patients and their caregivers anticipate—and overcome—the major challenges of eating well during treatment.

Written by Jeanne Besser, an award-winning cookbook author; Barbara Grant, a board.About Cancer: Cancer is a malignant growth or tumour resulting from an uncontrolled growth of abnormal cells.

The following list of medications are in some way related to, or used in the treatment of this condition. The following products are considered to be alternative treatments or natural remedies for Cancer.

Biological therapy for cancer is a type of treatment that uses the body's immune system to kill cancer cells. Biological therapy for cancer is used in the treatment of many types of cancer to prevent or slow tumor growth and to prevent the spread of cancer.

Biological therapy for cancer often causes fewer toxic side effects than do other cancer.